Severity | Reason for Immunocompromise | Core condition/state | Immunosuppressive medication or treatment | Patients (n) | ||
---|---|---|---|---|---|---|
Mild (n = 145) | Physiological | NA | 36 | 81 | ||
34 | ||||||
Age ≤ 2 [22] | 11 | |||||
Chronic Infectious Condition | HIV [19] | CD4 ≥ 500mm3 | NA | 26 | 33 | |
CD4 ≥ 200 < 500 mm [3] | 5 | |||||
Infectious liver disease | Cirrhosis, chronic hepatitis B | NA | 1 | |||
Partial liver secondary to parasitic cyst removal, disseminated candida | 1 | |||||
Chronic metabolic condition | Diabetes mellitus [22] | NA | 13 | 13 | ||
Malignancy | Solid cancer | Neuroendocrine tumour, with liver metastases | Radiotherapy < 12 months ago (localised radiotherapy) * | 1 | 1 | |
Immune modulated conditions on low dose immunosuppression | Bilateral uveitis | Low dose prednisolone < 20 mg/day [18] | 1 | 10 | ||
Psoriasis | Low dose oral methotrexate < 25 mg weekly [18] | 1 | ||||
Rheumatoid arthritis | 2 | |||||
Systemic lupus erythematous | 1 | |||||
Crohn’s disease | Low dose azathioprine < 3 mg/Kg/day [18] | 1 | ||||
PFAPA syndrome | 1 | |||||
Birdshot uveitis | Low dose MMF ≤ 1 g a day [18] | 1 | ||||
Dermatomyositis | azathioprine < 3 mg/Kg/day and prednisolone < 20 mg/day | 1 | ||||
Multiple sclerosis [7] | Interferon beta-1α injections | 1 | ||||
Hyposplenia | Sickle cell disease [7] | Hydroxycarbamide | 3 | 7 | ||
No treatment | 3 | |||||
Coeliac disease | NA | 1 |